反应详情

温度

100 °C

To a yellow suspension of 2 g 7-Bromo-1-tetralone, 1 g boronic acid, 7.1 g potassium phosphate (pulverized) and 0.28 g tricyclohexylphosphine in 40 ml toluene and 2 ml water 0.1 g of palladium acetate is added under a argon atmosphere. The mixture is heated to 100° C. After 1 h, the reaction mixture is allowed to cool to rt and quenched with water. The reaction mixture is extracted with EtOAc. The combined organic phases are washed with brine, dried over sodium sulfate and filtered. The brown oil is purified by flash-chromatography (hexane/EtOAc=6/1).

1. additionis added under a argon atmosphere
2. temperatureto cool to rt
3. customquenched with water
4. extractionThe reaction mixture is extracted with EtOAc
5. washThe combined organic phases are washed with brine
6. dry with materialdried over sodium sulfate
7. filtrationfiltered
8. customThe brown oil is purified by flash-chromatography (hexane/EtOAc=6/1)