Methyl iodide → HCID 57933498, compound

HRID 1432528Notes

Reaction equation

HRID 1432528 reaction equation
O[C:2]1[C:10]([O:11][C:12]([F:15])([F:14])[F:13])=[CH:9][CH:8]=[CH:7][C:3]=1C(O)=O.IC.[C:18](=O)([O-])[O-:19].[Cs+].[Cs+].[C:24]([O:27][CH2:28]C)(=[O:26])C>CN(C)C=O>[CH3:28][O:27][C:24](=[O:26])[C:7]1[CH:8]=[CH:9][C:10]([O:11][C:12]([F:13])([F:14])[F:15])=[CH:2][C:3]=1[O:19][CH3:18]

Participants

6

Reactant 4

HCID 6328Methyl iodideHCID 8857Ethyl AcetateHCID 10796Cesium carbonateHCID 121796552-Hydroxy-3-(trifluoromethoxy)benzoic acid

Product 1

HCID 57933498HCID 57933498, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1.0 g 2-hydroxy-(trifluoromethoxy)benzoic acid were dissolved in 30 ml dimethylformamide. 640 mg iodomethane and 4.70 g cesium carbonate were added and the reaction mixture was stirred at room temperature for three hours. The reaction mixture was diluted by addition of 100 ml ethyl acetate, washed with 30 ml water and brine and then dried over MgSO4. The solvent was removed in vacuo to obtain 590 mg 2-methoxy-4-trifluoromethoxy-benzoic acid methyl ester.

Workup

  1. washwashed with 30 ml water and brine
  2. dry with materialdried over MgSO4
  3. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-2cf99c6fa3fe431996e07d91acc4d7c9
Source dataset
uspto-grants-2009_11
Patent number
US07612104B2

Reaction notes

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