Triethylamine → HCID 57932987, compound

HRID 1432670Notes

Reaction equation

HRID 1432670 reaction equation
[CH2:1]([CH:3]([C:6]1[C:7]2[N:8]([C:13]([C:17]3[S:21][C:20]([NH:22][CH3:23])=[N:19][C:18]=3[CH3:24])=[C:14]([CH3:16])[N:15]=2)[N:9]=[C:10]([CH3:12])[CH:11]=1)[CH2:4][CH3:5])[CH3:2].C(N(CC)CC)C.[CH2:32]([S:34](Cl)(=[O:36])=[O:35])[CH3:33]>>[CH2:1]([CH:3]([C:6]1[C:7]2[N:8]([C:13]([C:17]3[S:21][C:20]([N:22]([CH3:23])[S:34]([CH2:32][CH3:33])(=[O:36])=[O:35])=[N:19][C:18]=3[CH3:24])=[C:14]([CH3:16])[N:15]=2)[N:9]=[C:10]([CH3:12])[CH:11]=1)[CH2:4][CH3:5])[CH3:2]

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 11667Ethanesulfonyl chlorideHCID 86620093HCID 86620093, compound

Product 1

HCID 57932987HCID 57932987, compoundYield 75%

Procedure

The title compound is prepared by a procedure analogous to Example 178. employing 50 mg of N-{5-[8-(1-ethyl-propyl)-2,6-dimethyl-imidazo[1,2-b]pyridazin-3-yl]-4-methyl-thiazol-2-yl}-methylamine (0.15 mmol), 51 mg of triethylamine (0.5 mmol) and 39 mg of ethanesulfonylchloride (0.3 mmol). 48.9 mg, Yield 75%: mass spectrum (m/e): 436 (M+1); 1H-NMR (CDCl3): 6.73 (s, 1H), 3.62 (s, 3H), 3.42 (q, 2H, J=7.4 Hz), 3.35 (m, 1H), 2.55 (s, 3H), 2.48 (s, 3H), 2.28 (s, 3H), 1.85 (m, 4H), 1.46 (t, 3H, J=7.4 Hz), 0.90 (t, 6H, J=7.5 Hz).

Sources & evidence

ORD record
ord-94ed994141684f87a3bf1ae6decf068c
Source dataset
uspto-grants-2009_11
Patent number
US07612067B2

Reaction notes

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