Water → HCID 178509641, compound

HRID 1432748Notes

Reaction equation

HRID 1432748 reaction equation
Cl[C:2]1[CH:9]=[C:8]([C:10]2[C:14]([C:15]([F:18])([F:17])[F:16])=[CH:13][NH:12][N:11]=2)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[F:19][C:20]([F:24])([F:23])[CH2:21][SH:22].C(=O)([O-])[O-].[K+].[K+].O>CN(C)C=O>[F:19][C:20]([F:24])([F:23])[CH2:21][S:22][C:2]1[CH:9]=[C:8]([C:10]2[C:14]([C:15]([F:18])([F:17])[F:16])=[CH:13][NH:12][N:11]=2)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]

Participants

6

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 41339242,2,2-TrifluoroethanethiolHCID 178509640HCID 178509640, compound

Product 1

HCID 178509641HCID 178509641, compoundYield 57.1%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

0.65 g (2.4 mmol) of 2-chloro-4-(4-trifluoromethylpyrazolyl)benzonitrile, 0.33 g (2.9 mmol) of 2,2,2-trifluoroethanthiol and 0.40 g (2.9 mmol) of potassium carbonate were stirred in 5 ml of N,N-dimethylformamide at room temperature overnight. The resulting reaction mixture was poured into 50 ml of water, and the organic matters were extracted with 20 ml of ethyl acetate twice. The ethyl acetate layers were combined, washed with 30 ml of water twice and dried over anhydrous magnesium sulfate, and the ethyl acetate was distilled off under reduced pressure. Purification of the residue by silica gel column chromatography afforded 0.48 g of 2-(2,2,2-trifluoroethylthio)-4-(4-trifluoromethylpyrazolyl)benzonitrile (yield 57.1%) as a milk-white powder (m.p. 90-91° C.).

Workup

  1. customThe resulting reaction mixture
  2. extractionthe organic matters were extracted with 20 ml of ethyl acetate twice
  3. washwashed with 30 ml of water twice
  4. dry with materialdried over anhydrous magnesium sulfate
  5. distillationthe ethyl acetate was distilled off under reduced pressure
  6. customPurification of the residue by silica gel column chromatography

Sources & evidence

ORD record
ord-8288bb687bdb44af9e28f9cce57e9d7d
Source dataset
uspto-grants-2009_11
Patent number
US07612105B2

Reaction notes

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