反应详情

(3 S,5RS)-1-(4-Amino-quinazolin-7-ylmethyl)-3,5-dimethyl-piperazin-2-one (260 mg, 0.56 mmol), EXAMPLE 88, is dissolved in 5 mL of DMF. Potassium carbonate (193.4 mg, 1.4 mmol) is added followed by the addition of 2-bromomethyl-6-chloro-benzo[b]thiophene (218 mg, 0.84 mmol), EXAMPLE 5. Reaction is left to stir overnight. The crude mixture is purified by reverse phase HPLC (10-70% ACN/H2O) to afford the product (27 mg, 6%) as a clear wax with a melting point of 130-131° C. C24H24ClN5OS MS m/z: 466, 468.

1. customReaction
2. waitis left
3. customThe crude mixture is purified by reverse phase HPLC (10-70% ACN/H2O)