反应详情

温度

85 °C

4-{4-[4-(2-{[(2R)-2-[4-(benzyloxy)-3-(hydroxymethyl)phenyl]-2-{[tert-butyl(dimethyl)silyl]oxy}ethyl]amino}ethyl)phenoxy]butyl}-2-[(1R)-3-(diisopropylamino)-1-phenylpropyl]phenol (Preparation 62, 388 mg, 0.44 mmol) was dissolved in ethanol (5 ml) and ammonium formate (280 mg, 4.44 mmol) and 20% palladium hydroxide on carbon (58 mg) added. The stirred reaction was heated at 85° C. for 18 hours. After cooling to room temperature, further ammonium formate (140 mg, 2.22 mmol) and 20% palladium hydroxide on carbon (20 mg) were added and mixture stirred at 85° C. for 3 hours. Reaction mixture was then cooled and filtered through Arbocel™, the filtrate was collected and the solvent removed in vacuo to furnish the title compound as a glass, 311 mg.

1. customThe stirred reaction
2. temperatureAfter cooling to room temperature
3. customReaction mixture
4. temperaturewas then cooled
5. filtrationfiltered through Arbocel™
6. customthe filtrate was collected
7. customthe solvent removed in vacuo