反应详情

温度

70 °C

After adding trifluoroacetic acid (30 ml) and thioanisole (3 ml) to 7-benzyloxy-6-methoxy-4-(4-nitrophenoxy)quinoline (4.0 g), the mixture was heated and stirred at 70° C. for 2 hours. After cooling the reaction solution, it was concentrated under reduced pressure, sodium bicarbonate water and methanol were added and the precipitated crystals were filtered out. They were then washed with diethyl ether to obtain 4.0 g of the title compound.

1. temperaturethe mixture was heated
2. temperatureAfter cooling the reaction solution, it
3. concentrationwas concentrated under reduced pressure, sodium bicarbonate water and methanol
4. additionwere added
5. filtrationthe precipitated crystals were filtered out
6. washThey were then washed with diethyl ether