HCID 69052229, compound → HCID 69057404, compound

HRID 1434527Notes

Reaction equation

HRID 1434527 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[N:11]1[CH2:17][CH2:16][CH2:15][CH2:14][O:13][C:12]1=[O:18].[H][H]>O1CCCC1.[Ni]>[NH2:8][C:6]1[CH:5]=[CH:4][C:3]([N:11]2[CH2:17][CH2:16][CH2:15][CH2:14][O:13][C:12]2=[O:18])=[C:2]([CH3:1])[CH:7]=1

Participants

5

Reactant 2

HCID 69052229HCID 69052229, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 69057404HCID 69057404, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 8028TetrahydrofuranSolvent

Procedure

1.95 g (7.79 mmol) 3-(2-methyl-4-nitro-phenyl)-[1,3]oxazepan-2-one are dissolved in 200 ml of tetrahydrofuran and combined with 700 mg Raney nickel. The mixture is hydrogenated in a Parr apparatus at ambient temperature at 1 bar hydrogen pressure for four hours. Then the catalyst is filtered off and the filtrate is evaporated down i. vac.

Workup

  1. filtrationThen the catalyst is filtered off
  2. customthe filtrate is evaporated down i

Sources & evidence

ORD record
ord-51e22662421c45bd8a4f3273aa83b56a
Source dataset
uspto-grants-2009_11
Patent number
US07615549B2

Reaction notes

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