L-Tartaric acid → 2,3-Dihydroxybutanedioic Acid

HRID 1434662Notes

Reaction equation

HRID 1434662 reaction equation
[C:1]([OH:10])(=[O:9])[C@@H:2]([C@H:4]([C:6]([OH:8])=[O:7])[OH:5])[OH:3]>CC(C)=O>[C:1]([OH:10])(=[O:9])[CH:2]([CH:4]([C:6]([OH:8])=[O:7])[OH:5])[OH:3]

Participants

3

Reactant 1

HCID 444305L-Tartaric acid

Product 1

HCID 8752,3-Dihydroxybutanedioic AcidYield 375%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

In the reaction flask, 10 gm of the oil obtained as per Example 1 was taken in 150 ml of acetone. To this 3.6 gm of L-(+)-tartaric acid was added and mixed at reflux temperature for about 2-3 hours. Acetone was distilled to obtain 13.5 gm of tartaric acid salt of benzyl perindopril.

Workup

  1. additionmixed
  2. temperatureat reflux temperature for about 2-3 hours
  3. distillationAcetone was distilled

Sources & evidence

ORD record
ord-6ee890a64e4a475baa26a673342c76bf
Source dataset
uspto-grants-2009_11
Patent number
US07615571B2

Reaction notes

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