Hydrochloric Acid → HCID 68983508, compound

HRID 1434834Notes

Reaction equation

HRID 1434834 reaction equation
[NH2:1][CH2:2][CH2:3][O:4][C:5]1[CH:29]=[C:28]([S:30]([CH3:33])(=[O:32])=[O:31])[CH:27]=[CH:26][C:6]=1[C:7]([NH:9][C:10]1[C:11]([C:16]([NH:18][C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][N:20]=2)=[O:17])=[N:12][CH:13]=[CH:14][CH:15]=1)=[O:8].Cl>CO.C(Cl)Cl>[ClH:25].[NH2:1][CH2:2][CH2:3][O:4][C:5]1[CH:29]=[C:28]([S:30]([CH3:33])(=[O:31])=[O:32])[CH:27]=[CH:26][C:6]=1[C:7]([NH:9][C:10]1[C:11]([C:16]([NH:18][C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][N:20]=2)=[O:17])=[N:12][CH:13]=[CH:14][CH:15]=1)=[O:8]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57936549HCID 57936549, compound

Product 1

HCID 68983508HCID 68983508, compoundYield 190%

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

To a mixture of 3-[2-(2-aminoethoxy)-4-methylsulfonyl-benzoylamino]-N-(5-chloropyridin-2-yl)pyridine-2-carboxamide (3.17 g, 6.5 mmol) and 10% MeOH/CH2Cl2 (250 mL) was added 5 N HCl. After stirring for 1 hour, the mixture was concentrated to give the desired product as a solid (3.25 g, 96%).

Workup

  1. concentrationthe mixture was concentrated

Sources & evidence

ORD record
ord-2920abca8fe144e4880ca3b632d10e68
Source dataset
uspto-grants-2009_11
Patent number
US07615568B2

Reaction notes

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