Hydrochloric Acid → HCID 68983189, compound

HRID 1434850Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9]([C:11]2[C:16]([NH:17][C:18](=[O:38])[C:19]3[CH:24]=[CH:23][C:22]([S:25]([CH3:28])(=[O:27])=[O:26])=[CH:21][C:20]=3[O:29][CH2:30][C@H:31]([CH3:37])[CH:32]=[N:33]C(C)C)=[CH:15][CH:14]=[CH:13][N:12]=2)=[O:10])=[N:6][CH:7]=1.Cl>>[ClH:1].[NH2:33][CH2:32][C@@H:31]([CH3:37])[CH2:30][O:29][C:20]1[CH:21]=[C:22]([S:25]([CH3:28])(=[O:26])=[O:27])[CH:23]=[CH:24][C:19]=1[C:18]([NH:17][C:16]1[C:11]([C:9]([NH:8][C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][N:6]=2)=[O:10])=[N:12][CH:13]=[CH:14][CH:15]=1)=[O:38]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 68982627HCID 68982627, compound

Product 1

HCID 68983189HCID 68983189, compoundYield 69%

Procedure

N-(5-Chloropyridin-2-yl)-3-[2-[(2R)-2-methyl-3-(2-propylimino)propoxy]-4-methylsulfonylbenzoylamino]-pyridine-2-carboxamide was treated with 1 N HCl and purified by HPLC (Vydac C18, 5-70% 0.1% TFA/CH3CN in 0.1% TFA/H2O; Rt: 27.6 m) to give the title compound as a solid (205 mg, 69%).

Workup

custompurified by HPLC (Vydac C18, 5-70% 0.1% TFA/CH3CN in 0.1% TFA/H2O; Rt: 27.6 m)

Sources & evidence

ORD record: ord-2c2f587f2c554192a98c2d79f6acac4a
Source dataset: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07615568B2

Reaction notes

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