4-Chloro-2-methylthiopyrimidine → HCID 57936139, compound

HRID 1434932Notes

Reaction equation

HRID 1434932 reaction equation
CC([Si](C(C)C)(C(C)C)[N:5]1[CH:9]=[CH:8][C:7](B(O)O)=[CH:6]1)C.Cl[C:20]1[CH:25]=[CH:24][N:23]=[C:22]([S:26][CH3:27])[N:21]=1>>[CH3:27][S:26][C:22]1[N:23]=[C:24]([C:7]2[CH:8]=[CH:9][NH:5][CH:6]=2)[CH:25]=[CH:20][N:21]=1

Participants

3

Reactant 2

HCID 971134-Chloro-2-methylthiopyrimidineHCID 27633031-(Triisopropylsilyl)pyrrole-3-boronic acid

Product 1

HCID 57936139HCID 57936139, compoundYield 95%

Procedure

The title compound was prepared analogous to Step A of Method B, starting from [1-[tris(1-methylethyl)silyl]-1H-pyrrol-3-yl]-boronic acid and 4-chloro-2-methylsulfanyl-pyrimidine. Under the reaction conditions, the triisopropylsilyl protecting group was cleaved. Yield: 95%.

Workup

  1. customUnder the reaction conditions

Sources & evidence

ORD record
ord-50ae74be66bf46e9a45473fcec975560
Source dataset
uspto-grants-2009_11
Patent number
US07615562B2

Reaction notes

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