Hydrochloric Acid → HCID 11292158, compound

HRID 1434939Notes

Reaction equation

HRID 1434939 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH:8][CH:9]2[CH2:14][C:13]([CH3:16])([CH3:15])[NH:12][C:11]([CH3:18])([CH3:17])[CH2:10]2)[N:3]=1.C(OC(=O)[NH:25][C:26]([CH3:34])([CH3:33])[CH2:27][C:28]1[S:29][CH:30]=[CH:31][CH:32]=1)(C)(C)C.Cl>O1CCOCC1>[NH2:25][C:26]([CH3:34])([CH3:33])[CH2:27][C:28]1[S:29][C:30]([C:2]2[CH:7]=[CH:6][N:5]=[C:4]([NH:8][CH:9]3[CH2:14][C:13]([CH3:16])([CH3:15])[NH:12][C:11]([CH3:18])([CH3:17])[CH2:10]3)[N:3]=2)=[CH:31][CH:32]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 57936167(4-Chloro-pyrimidin-2-yl)(2,2,6,6-tetramethyl-piperidin-4-yl)-amineHCID 69065499HCID 69065499, compound

Product 1

HCID 11292158HCID 11292158, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The title compound was prepared analogous to Method C, starting from (4-chloro-pyrimidin-2-yl)-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine and (1,1-Dimethyl-2-thiophen-2-yl-ethyl)-carbamic acid tert-butyl ester (prepared by BOC protection of 1,1-Dimethyl-2-thiophen-2-yl-ethylamine), followed by BOC cleavage with HCl in dioxane.

Sources & evidence

ORD record
ord-0269310b9ffd4a18be7df966745895b9
Source dataset
uspto-grants-2009_11
Patent number
US07615562B2

Reaction notes

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