Hydrochloric Acid → HCID 57936176, compound

HRID 1434954Notes

Reaction equation

HRID 1434954 reaction equation
C([O:3][C:4]([C:6]1[S:7][C:8]([C:11]2[CH:16]=[CH:15][N:14]=[C:13]([NH:17][CH:18]3[CH2:23][C:22]([CH3:25])([CH3:24])[NH:21][C:20]([CH3:27])([CH3:26])[CH2:19]3)[N:12]=2)=[CH:9][CH:10]=1)=[O:5])C.[OH-].[Na+].Cl>CO>[CH3:24][C:22]1([CH3:25])[CH2:23][CH:18]([NH:17][C:13]2[N:12]=[C:11]([C:8]3[S:7][C:6]([C:4]([OH:5])=[O:3])=[CH:10][CH:9]=3)[CH:16]=[CH:15][N:14]=2)[CH2:19][C:20]([CH3:27])([CH3:26])[NH:21]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 57936347HCID 57936347, compound

Product 1

HCID 57936176HCID 57936176, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

5-[2-(2,2,6,6-Tetramethyl-piperidin-4-ylamino)-pyrimidin-4-yl]-thiophene-2-carboxylic acid ethyl ester (4.90 g, 12.6 mmol) were dissolved in methanol (50 ml). After addition of sodium hydroxide (31 ml of a 40% solution) the mixture was stirred at room temperature overnight. The reaction mixture was acidified using 1N HCl and the product was collected by filtration (4.50 g, 12.5 mmol).

Workup

  1. filtrationthe product was collected by filtration (4.50 g, 12.5 mmol)

Sources & evidence

ORD record
ord-ddcfcef1589b49eeb915bbe40d8e79cf
Source dataset
uspto-grants-2009_11
Patent number
US07615562B2

Reaction notes

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