HCID 57936114, compound → HCID 136119650, compound

HRID 1434970Notes

Reaction equation

HRID 1434970 reaction equation
C[O:2][C:3]1[CH:4]=[CH:5][C:6]2[CH:10]=[C:9]([C:11]3[CH:16]=[CH:15][N:14]=[C:13]([NH:17][CH:18]4[CH2:23][C:22]([CH3:25])([CH3:24])[NH:21][C:20]([CH3:27])([CH3:26])[CH2:19]4)[N:12]=3)[S:8][C:7]=2[CH:28]=1>Br>[CH3:24][C:22]1([CH3:25])[CH2:23][CH:18]([NH:17][C:13]2[N:12]=[C:11]([C:9]3[S:8][C:7]4[CH:28]=[C:3]([OH:2])[CH:4]=[CH:5][C:6]=4[CH:10]=3)[CH:16]=[CH:15][N:14]=2)[CH2:19][C:20]([CH3:27])([CH3:26])[NH:21]1

Participants

3

Reactant 1

HCID 57936114HCID 57936114, compound

Product 1

HCID 136119650HCID 136119650, compound

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Conditions

Temperature
120 °C

Procedure

Compound of Example 152 (200 mg, 0.5 mmol) was dissolved in 10 ml hydrobromic acid 48% and stirred at 120° C. for 20 hours. Afterwards the mixture was evaporated and the crude was purified by chromatography on silicagel (DCM/MeOH/ammonia:8/2/0.2). Yield: 120 mg (62%).

Workup

  1. customAfterwards the mixture was evaporated
  2. customthe crude was purified by chromatography on silicagel (DCM/MeOH/ammonia:8/2/0.2)

Sources & evidence

ORD record
ord-d574cbccf9564b8eb593d34c2e5e14ed
Source dataset
uspto-grants-2009_11
Patent number
US07615562B2

Reaction notes

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