HCID 57937845, compound → HCID 57937842, compound

HRID 1435073Notes

Reaction equation

HRID 1435073 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8][OH:9])[CH:5]=[CH:4][C:3]=1[C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([NH2:18])=[O:17])[CH:11]=1>C(OCC)(=O)C.[O-2].[O-2].[Mn+4]>[Cl:1][C:2]1[CH:7]=[C:6]([CH:8]=[O:9])[CH:5]=[CH:4][C:3]=1[C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([NH2:18])=[O:17])[CH:11]=1

Participants

4

Reactant 1

HCID 57937845HCID 57937845, compound

Product 1

HCID 57937842HCID 57937842, compound

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 8857Ethyl AcetateSolvent

Procedure

2′-Chloro-4′-hydroxymethyl-biphenyl-3-carboxylic acid amide (I-6d: 5.0 g) was suspended in 500 mL of ethyl acetate and treated with activated manganese dioxide (5 equivalents). After stirring for 12 hours, the reaction mixture was filtered through a pad of Celite and concentrated under reduced pressure to afford the title compound (I-6e).

Workup

  1. filtrationthe reaction mixture was filtered through a pad of Celite
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-ab80f2099cd144e6bb3947bd7c7fc888
Source dataset
uspto-grants-2009_11
Patent number
US07615651B2

Reaction notes

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