HCID 57937843, compound → HCID 57937815, compound

HRID 1435075Notes

Reaction equation

[C:1]([O:5][C:6](=[O:30])[N:7]([CH2:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([C:26](=[O:28])[NH2:27])[CH:21]=2)=[C:16]([F:29])[CH:15]=1)[CH2:8][CH2:9][CH:10]([CH3:12])[CH3:11])([CH3:4])([CH3:3])[CH3:2]>COC(OC)N(C)C>[C:1]([O:5][C:6](=[O:30])[N:7]([CH2:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([C:26](=[O:28])[N:27]=[CH:6][N:7]([CH3:13])[CH3:8])[CH:21]=2)=[C:16]([F:29])[CH:15]=1)[CH2:8][CH2:9][CH:10]([CH3:12])[CH3:11])([CH3:3])([CH3:4])[CH3:2]

Participants

Conditions

Temperature: 120 °C

Procedure

(3′-Carbamoyl-2-fluoro-biphenyl-4-ylmethyl)-(3-methyl-butyl)-carbamic acid tert-butyl ester (I-5e; 0.8 g, 1.92 mmol) was dissolved in dimethylformamide dimethyl acetal (10 ml) and heated to 120° C. for 2 hours. The reaction mixture was then cooled to room temperature and volatiles were removed under reduced pressure. The crude residue (0.9 g) used in the next reaction without purification. Mass Spec.: (m/z+1=470).

Workup

temperatureThe reaction mixture was then cooled to room temperature
customvolatiles were removed under reduced pressure
customThe crude residue (0.9 g) used in the next reaction without purification

Sources & evidence

ORD record: ord-8699da291e344d4aab5f484b5f7432b2
Source dataset: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07615651B2

Reaction notes

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