Triethylamine → HCID 56673352, compound

HRID 1435329Notes

Reaction equation

HRID 1435329 reaction equation
[NH2:1][C:2]1[C:7]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[O:9])=[CH:6][N:5]=[C:4](S(C)=O)[N:3]=1.FC(F)(F)C(O)=O.[CH3:26][S:27]([N:30]1[CH2:35][CH2:34][CH:33]([NH2:36])[CH2:32][CH2:31]1)(=[O:29])=[O:28].C(N(CC)CC)C>C(O)C>[NH2:1][C:2]1[C:7]([C:8]([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)=[O:9])=[CH:6][N:5]=[C:4]([NH:36][CH:33]2[CH2:34][CH2:35][N:30]([S:27]([CH3:26])(=[O:29])=[O:28])[CH2:31][CH2:32]2)[N:3]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 11975076[1-(Methylsulfonyl)piperidin-4-yl]amine trifluoroacetateHCID 21070606HCID 21070606, compound

Product 1

HCID 56673352HCID 56673352, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Treatment of the material prepared in Example 282 with material prepared in Example 162 in ethanol containing triethylamine at reflux for one hour, gave, after chilling and filtering, [4-amino-2-(1-methanesulfonyl-piperidin-4-ylamino)-pyrimidin-5-yl]-phenyl-methanone, as a colorless solid, MP 249-250° C. MS(ES) MH+376

Workup

  1. temperatureat reflux for one hour
  2. customgave
  3. temperatureafter chilling
  4. filtrationfiltering

Sources & evidence

ORD record
ord-91a99ca0f5404055a106a9d1c3d58a2b
Source dataset
uspto-grants-2009_11
Patent number
US07615634B2

Reaction notes

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