Potassium hydroxy sulfite → HCID 178441540, compound

HRID 1435535Notes

Reaction equation

HRID 1435535 reaction equation
[C:1]([C:5]1[N:9]([CH2:10][C@H:11]2[CH2:16][CH2:15][C@H:14]([F:17])[CH2:13][CH2:12]2)[C:8]2[CH:18]=[CH:19][C:20]([S:22]([N:25]3[CH:29]=[C:28]([CH:30]=[O:31])[CH:27]=[N:26]3)(=[O:24])=[O:23])=[CH:21][C:7]=2[N:6]=1)([CH3:4])([CH3:3])[CH3:2].[OH:32]OS([O-])=O.[K+]>CN(C=O)C>[C:1]([C:5]1[N:9]([CH2:10][C@H:11]2[CH2:16][CH2:15][C@H:14]([F:17])[CH2:13][CH2:12]2)[C:8]2[CH:18]=[CH:19][C:20]([S:22]([N:25]3[CH:29]=[C:28]([C:30]([OH:32])=[O:31])[CH:27]=[N:26]3)(=[O:24])=[O:23])=[CH:21][C:7]=2[N:6]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 23707502Potassium hydroxy sulfiteHCID 178441539HCID 178441539, compound

Product 1

HCID 178441540HCID 178441540, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1-({2-tert-Butyl-1-[(trans-4-fluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}sulfonyl)-1H-pyrazole-4-carbaldehyde (130 mg, 0.291 mmol) and oxone (215 mg, 0.349 mmol) were stirred in 10 mL of DMF at rt overnight. The solvent was evaporated. The residue was dissolved in DCM and washed with water, brine and dried over anhydrous MgSO4. Yield: 135 mg (99%). MS (ESI) (M+H)+=463.06.

Workup

  1. customThe solvent was evaporated
  2. dissolutionThe residue was dissolved in DCM
  3. washwashed with water, brine
  4. dry with materialdried over anhydrous MgSO4

Sources & evidence

ORD record
ord-810aade65a274502a0ddc1c2584473a8
Source dataset
uspto-grants-2009_11
Patent number
US07615642B2

Reaction notes

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