反应详情

温度

70 °C

Potassium tert-butoxide (2.25 g, 20 mmol) was added to a solution of N-[4-(2-amino-5-nitro-pyridin-3-ylethynyl)-phenyl]-acetamide (1.48 g, 5 mmol) in a 2:1 mixture of tetrahydrofuran and dimethylformamide (75 mL). The mixture was heated at 70° C. for 16 hours then the tetrahydrofuran was removed in vacuo. The mixture was poured onto a pad of silica and eluted with 10% methanol in ethyl acetate. The organics were concentrated in vacuo to 5% of their original volume and water (30 mL) was added. The resultant orange solid was filtered and dried to afford N-[3-(5-Nitro-1H-pyrrolo[2,3-b]pyridin-2-yl)-phenyl]-acetamide (1.01 g, 68%).

1. customthe tetrahydrofuran was removed in vacuo
2. additionThe mixture was poured onto a pad of silica
3. washeluted with 10% methanol in ethyl acetate
4. concentrationThe organics were concentrated in vacuo to 5% of their original volume and water (30 mL)
5. additionwas added
6. filtrationThe resultant orange solid was filtered
7. customdried