Bis(2-Methoxyethyl)amine → HCID 178495927, compound

HRID 1435591Notes

Reaction equation

HRID 1435591 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:9]2[NH:20][C:12]3=[N:13][CH:14]=[C:15]([N+:17]([O-:19])=[O:18])[CH:16]=[C:11]3[N:10]=2)[CH:5]=[CH:6][C:7]=1F.[CH3:21][O:22][CH2:23][CH2:24][NH:25][CH2:26][CH2:27][O:28][CH3:29]>CN1C(=O)CCC1>[F:1][C:2]1[CH:3]=[C:4]([C:9]2[NH:20][C:12]3=[N:13][CH:14]=[C:15]([N+:17]([O-:19])=[O:18])[CH:16]=[C:11]3[N:10]=2)[CH:5]=[CH:6][C:7]=1[N:25]([CH2:26][CH2:27][O:28][CH3:29])[CH2:24][CH2:23][O:22][CH3:21]

Participants

4

Reactant 2

HCID 2383Bis(2-Methoxyethyl)amineHCID 178526788HCID 178526788, compound

Product 1

HCID 178495927HCID 178495927, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

0.5 g 2-(3,4-Difluoro-phenyl)-6-nitro-3H-imidazo[4,5-b]pyridine, 0.1 ml NMP and 0.51 g bis(2-methoxyethyl)-amine were heated to 170 C with stirring for 18 hrs. Volatile materials were removed under vacuum and the residue purified by chromatography, first on silica in dichloromethane/methanol mixtures, and subsequently by preparative HPLC.

Workup

  1. customVolatile materials were removed under vacuum
  2. customthe residue purified by chromatography, first on silica in dichloromethane/methanol mixtures

Sources & evidence

ORD record
ord-0216c88c746f4e9c8bfb0b9a0d7d5379
Source dataset
uspto-grants-2009_11
Patent number
US07618964B2

Reaction notes

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