Methylamine → HCID 10132894, compound

HRID 1435759Notes

Reaction equation

HRID 1435759 reaction equation
Cl[C:2]1[N:7]=[C:6](Cl)[N:5]=[C:4]([C:9]2[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=2[CH3:16])[N:3]=1.[NH2:17][C:18]1[CH:25]=[CH:24][C:21]([CH2:22][OH:23])=[CH:20][CH:19]=1.[CH3:26][NH2:27]>>[Cl:15][C:13]1[CH:12]=[CH:11][C:10]([CH3:16])=[C:9]([C:4]2[N:5]=[C:6]([NH:27][CH3:26])[N:7]=[C:2]([NH:17][C:18]3[CH:25]=[CH:24][C:21]([CH2:22][OH:23])=[CH:20][CH:19]=3)[N:3]=2)[CH:14]=1

Participants

4

Reactant 3

HCID 6329MethylamineHCID 693314-Aminobenzyl alcoholHCID 858270322,4-Dichloro-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazine

Product 1

HCID 10132894HCID 10132894, compoundYield 81%

Procedure

The reaction of 2,4-dichloro-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazine and 4-aminobenzyl alcohol using the method described in Example 67 and using methylamine in place of ammonia provided the title compound (81% yield). 1H NMR (acetone-d6) δ 8.75, 8.62 (2br s, 1H), 8.02-7.82 (m, 3H), 7.41-7.28 (m, 4H), 6.83 (br s, 1H), 4.62-4.59 (m, 2H), 4.10-4.05 (m, 1H), 3.05, 3.01 (2s, 3H), 2.67, 2.59 (2s, 3H).

Sources & evidence

ORD record
ord-5c9f2de55d4f4b4bba4d1e9875bf1823
Source dataset
uspto-grants-2009_11
Patent number
US07618968B2

Reaction notes

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