反应详情

温度

150 °C

Sodium cyanoborohydride (61 mg; 0.97 mmol ) was added to 3-(1H-indol-3-yl)-indan-1-one (200 mg; 0.81 mmol ) and piperidine (344 mg; 4.05 mmol ) in 3 mL methanol and 0.5 mL acetic acid. The reaction mixture was stirred 30 minutes at 150° C. under microwave irradiation using the Emry Optimizer™ instrument. The reaction mixture was poured into water and made basic with 27% aqueous NaOH. The mixture was extracted with ethyl acetate. The organic phase was dried over MgSO4 and concentrated in vacuo. cis-3-(3-Piperidin-1-yl-indan-1-yl)-1H-indole was obtained after flash chromatography (ethyl acetate, heptane, triethylamine, silica gel).

1. extractionThe mixture was extracted with ethyl acetate
2. dry with materialThe organic phase was dried over MgSO4
3. concentrationconcentrated in vacuo