Sodium Hydroxide → 2-Oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]thiazine-7-carboxylic acid

HRID 1435861Notes

Reaction equation

HRID 1435861 reaction equation
C[O:2][C:3]([C:5]1[CH:15]=[N:14][C:8]2[S:9][CH2:10][C:11](=[O:13])[NH:12][C:7]=2[CH:6]=1)=[O:4].[OH-].[Na+]>O1CCCC1>[O:13]=[C:11]1[CH2:10][S:9][C:8]2[N:14]=[CH:15][C:5]([C:3]([OH:4])=[O:2])=[CH:6][C:7]=2[NH:12]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 17981264Methyl 2-oxo-2,3-dihydro-1h-pyrido[2,3-b][1,4]thiazine-7-carboxylate

Product 1

HCID 218736922-Oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]thiazine-7-carboxylic acidYield 95.2%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2-Oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]thiazine-7-carboxylic acid methyl ester (2.8 g) was hydrolyzed with aqueous sodium hydroxide in tetrahydrofuran by the method of Preparation (14a) to afford a solid (2.5 g). MS (−ve ion electrospray) m/e 209 (M−H−).

Sources & evidence

ORD record
ord-0ed83751c27f4186bd16e382ef7600a2
Source dataset
uspto-grants-2009_11
Patent number
US07618959B2

Reaction notes

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