反应详情

温度

78 °C

To a mixture of 1-chloro-6,7-dihydro-8H-pyrido[3,4-b]pyrrolizin-8-one (5.0 g, 24.3 mmol), tris (dibenzylidene acetone)dipalladium (0) (1.0 g, 1.09 mmol) and triphenylarsine (2.70 g, 8.82 mmol) in DMF (100 mL) was added tributylisopropenyl stannane (9.60 g, 29.00 mmol). The resulting mixture was degassed and heated at 78° C. for a period of 18 h. The solvant was evaporated under reduced pressure. CH2Cl2 and celite were added to the resulting mixture which was then filtered over celite. The title compound was purified by flash chromatography (50% to 100% EtOAc in Hexane).

1. customThe resulting mixture was degassed
2. customThe solvant was evaporated under reduced pressure
3. additionCH2Cl2 and celite were added to the resulting mixture which
4. filtrationwas then filtered over celite
5. customThe title compound was purified by flash chromatography (50% to 100% EtOAc in Hexane)