Hydrochloride methanol → Hydrochloric Acid

HRID 1436040Notes

Reaction equation

HRID 1436040 reaction equation
C(O[C:6]([N:8]([CH:10]1[CH2:14][CH2:13][N:12]([S:15]([C:18]2[C:19]3[C:20]([Br:28])=[CH:21][N:22]=[CH:23][C:24]=3[CH:25]=[CH:26][CH:27]=2)(=[O:17])=[O:16])[CH2:11]1)C)=O)(C)(C)C.[ClH:29].CO>>[Br:28][C:20]1[C:19]2[C:18]([S:15]([N:12]3[CH2:13][CH2:14][CH:10]([NH:8][CH3:6])[CH2:11]3)(=[O:16])=[O:17])=[CH:27][CH:26]=[CH:25][C:24]=2[CH:23]=[N:22][CH:21]=1.[ClH:29]

Participants

4

Reactant 2

HCID 21893726Hydrochloride methanolHCID 67243419HCID 67243419, compound

Product 2

HCID 313Hydrochloric AcidHCID 67242317HCID 67242317, compound

Procedure

Intermediate 20 (0.157 g) prepared in Step A mentioned above is added with 10% hydrogen chloride/methanol (2 ml), and the mixture is stirred at room temperature for 12 hours. The solvent is evaporated under reduced pressure to obtain the title compound as hydrochloride (125 mg (predictive yield)).

Workup

  1. customThe solvent is evaporated under reduced pressure

Sources & evidence

ORD record
ord-dc3c812f30fd41919d23750e65b4bbc1
Source dataset
uspto-grants-2009_11
Patent number
US07618984B2

Reaction notes

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