(r/s)-3-(Tert-butoxycarbonyl)amino-1-(1-amino-4-chloro-5-isoquinolinesulfonyl)-pyrrolidine → Hydrochloric Acid

HRID 1436056Notes

Reaction equation

HRID 1436056 reaction equation
C(OC([NH:8][CH:9]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[C:18]3[C:19]([Br:28])=[CH:20][N:21]=[C:22]([Cl:27])[C:23]=3[CH:24]=[CH:25][CH:26]=2)(=[O:16])=[O:15])[CH2:10]1)=O)(C)(C)C.C(OC([NH:36]C1CCN(S(C2C3C(Cl)=CN=C(N)C=3C=CC=2)(=O)=O)C1)=O)(C)(C)C>>[NH2:8][CH:9]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[C:18]3[C:19]([Br:28])=[CH:20][N:21]=[C:22]([NH2:36])[C:23]=3[CH:24]=[CH:25][CH:26]=2)(=[O:16])=[O:15])[CH2:10]1.[ClH:27]

Participants

4

Reactant 2

HCID 67243409(r/s)-3-(Tert-butoxycarbonyl)amino-1-(1-amino-4-chloro-5-isoquinolinesulfonyl)-pyrrolidineHCID 87322137(r/s)-3-(Tert-butoxycarbonylamino)-1-(1-chloro-4-bromo-5-isoquinolinesulfonyl)pyrrolidine

Product 2

HCID 313Hydrochloric AcidHCID 67243187(r/s)-3-Amino-1-(1-amino-4-bromo-5-isoquinolinesulfonyl)pyrrolidine

Procedure

Intermediate 29 is used in the method of Example 39, Step B instead of Intermediate 28 to obtain the title compound as hydrochloride.

Sources & evidence

ORD record
ord-7d44d34b8b9847d9be7af8cf5a5c6262
Source dataset
uspto-grants-2009_11
Patent number
US07618984B2

Reaction notes

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