Hydrogen Bromide → HCID 17967165, compound

HRID 1436060Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([CH2:14][NH:15][CH2:16][CH:17]3[CH2:26][CH2:25][C:24]4[C:19](=[CH:20][C:21]([O:27]C)=[CH:22][CH:23]=4)[O:18]3)[CH:11]=[N:12][CH:13]=2)=[CH:4][CH:3]=1.[BrH:29]>>[BrH:29].[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([CH2:14][NH:15][CH2:16][CH:17]3[CH2:26][CH2:25][C:24]4[C:19](=[CH:20][C:21]([OH:27])=[CH:22][CH:23]=4)[O:18]3)[CH:11]=[N:12][CH:13]=2)=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 260Hydrogen Bromide

HCID 19079379HCID 19079379, compound

Product 1

HCID 17967165HCID 17967165, compound

Procedure

300 mg of (2R/S)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-7-methoxychroman is treated with 25 ml hydrobromic acid (48% in water) at 130 degrees C. The obtained red solution is neutralized and worked up as described in example 1. 130 mg of (2R/S)-2-({[5-(4-fluorophenyl)-pyridin-3ylmethyl]-amino}-methyl)-chroman-7-ol hydrobromide is obtained;

Sources & evidence

ORD record: ord-543053483e2f4fc5b56871814207f4ae
Source dataset: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07618988B2

Reaction notes

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