Trifluoroacetic acid → (E)-5-chloro-2-{1-[3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl]methylidene]valeric acid trifluoroacetate

HRID 1436139ノート

反応式

HRID 1436139 の反応式
[C:1]([OH:7])([C:3]([F:6])([F:5])[F:4])=[O:2].[Cl:8][CH2:9][CH2:10][CH2:11]/[C:12](=[CH:20]\[C:21]1[CH:26]=[CH:25][C:24]([N:27]2[CH:31]=[C:30]([CH3:32])[N:29]=[CH:28]2)=[C:23]([F:33])[CH:22]=1)/[C:13]([O:15]C(C)(C)C)=[O:14]>C(Cl)(Cl)Cl>[F:4][C:3]([F:6])([F:5])[C:1]([OH:7])=[O:2].[Cl:8][CH2:9][CH2:10][CH2:11]/[C:12](=[CH:20]\[C:21]1[CH:26]=[CH:25][C:24]([N:27]2[CH:31]=[C:30]([CH3:32])[N:29]=[CH:28]2)=[C:23]([F:33])[CH:22]=1)/[C:13]([OH:15])=[O:14]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 69004836HCID 69004836、化合物

生成物 1

HCID 69003182(E)-5-chloro-2-{1-[3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl]methylidene]valeric acid trifluoroacetate

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

chloroform (5 mL) and TFA (10 mL) were added to tert-butyl(E)-5-chloro-2-{1-[3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl]methylidene}valerate (1.96 g), and the reaction solution was stirred at room temperature for one hour. The reaction solution was concentrated under reduced pressure. The residue was solidified with methylene chloride, ethyl acetate, and heptane and separated by filtration to obtain 2.19 g of the title compound. The property value of the compound is as follows.

後処理

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. customseparated by filtration

出典と根拠

ORDレコード
ord-752a50c8bdae414a99ca8b585a0166d8
出典データセット
uspto-grants-2009_11
特許番号
US07618960B2

反応ノート

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