反应详情

4-(2,2-Dimethyl-4-oxo-4H-benzo[1,3]dioxin-7-yloxy)-3-fluoro-benzaldehyde (I-1b-1: 24.8 g) and 2-cyclopropyl-ethylamine (6.2 g) were combined in 1,2-dichloroethane (1.0 L). After stirring at ambient temperature for 1 hour, sodium triacetoxyborohydride (83 g) was added to the solution. After stirring overnight, the reaction mixture was treated with an aqueous 2 N potassium hydroxide solution, the organic phase was separated, dried over magnesium sulfate, filtered, and evaporated to provide the title compound (I-1c-2).

1. stirringAfter stirring overnight
2. customthe organic phase was separated
3. dry with materialdried over magnesium sulfate
4. filtrationfiltered
5. customevaporated