Triethylamine → HCID 57939117, compound

HRID 1436357Notes

Reaction equation

[CH2:1]([O:3][P:4]([CH:9]([N:14]([C:24]([CH3:27])([CH3:26])[CH3:25])[O:15][CH:16]([C:18](=[O:23])[NH:19][CH2:20][CH2:21][OH:22])[CH3:17])[C:10]([CH3:13])([CH3:12])[CH3:11])(=[O:8])[O:5][CH2:6][CH3:7])[CH3:2].[C:28](Cl)(=[O:31])[CH:29]=[CH2:30].C(N(CC)CC)C>>[C:24]([N:14]([CH:9]([P:4]([O:5][CH2:6][CH3:7])([O:3][CH2:1][CH3:2])=[O:8])[C:10]([CH3:13])([CH3:12])[CH3:11])[O:15][CH:16]([CH3:17])[C:18]([NH:19][CH2:20][CH2:21][O:22][C:28](=[O:31])[CH:29]=[CH2:30])=[O:23])([CH3:26])([CH3:25])[CH3:27]

Participants

Reactant 3

HCID 8471Triethylamine

HCID 13140Acryloyl chloride

HCID 86760991HCID 86760991, compound

Product 1

HCID 57939117HCID 57939117, compound

Procedure

In analogy to Example 3C) are reacted 8.43 g (0.0205 mol) (1-{tert-butyl-[1-(2-hydroxy-ethylcarbamoyl)-ethoxy]-amino}-2,2-dimethyl-propyl)-phosphonic acid diethyl ester, 2.08 g (0.025 mol) acryloylchloride and 3.2 ml (0.025 mol) triethylamine to afford the title compound as two diastereomers: 4.79 g of a colorless oil and 3.5 g of a white solid, mp 95-98° C.

Sources & evidence

ORD record: ord-0075e226e741408782f79dfd2f506a7a
Source dataset: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07619050B2

Reaction notes

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