Diisopropylethylamine → HCID 25029877, compound

HRID 1436452Notes

Reaction equation

HRID 1436452 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([NH:13][C:14]([CH3:18])([CH3:17])[CH2:15][OH:16])[S:11][CH:12]=2)=[CH:4][C:3]=1[F:19].Cl[C:21](Cl)([O:23]C(=O)OC(Cl)(Cl)Cl)Cl.C(N(C(C)C)CC)(C)C>C(Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([N:13]3[C:14]([CH3:17])([CH3:18])[CH2:15][O:16][C:21]3=[O:23])[S:11][CH:12]=2)=[CH:4][C:3]=1[F:19]

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 94429TriphosgeneHCID 86618618HCID 86618618, compound

Product 1

HCID 25029877HCID 25029877, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In the same manner as described in step 7 of Example 78, using 2-[4-(4-chloro-3-fluoro-phenyl)-thiazol-2-ylamino]-2-methyl-propan-1-ol (810 mg, 2.66 mmol), prepared in the previous step, triphosgene (946 mg, 3.19 mmol) and diisopropylethyl amine (1.1 mL) in 20 mL of methylene chloride, the title compound was isolated (125 mg, 14%) after purification on silica gel using 6:1 hexane:ethyl acetate as the eluent. mp 140-142° C.

Sources & evidence

ORD record
ord-9c9be60eb2d0475299fcf07f1a1539c6
Source dataset
uspto-grants-2009_11
Patent number
US07618990B2

Reaction notes

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