Trifluoroacetic acid → 2-(S)-Amino-3-(3,5-difluorophenyl)-propan-1-ol trifluoroacetate

HRID 1436478Notes

Reaction equation

HRID 1436478 reaction equation
C(OC(=O)[NH:7][C@H:8]([CH2:18][OH:19])[CH2:9][C:10]1[CH:15]=[C:14]([F:16])[CH:13]=[C:12]([F:17])[CH:11]=1)(C)(C)C.[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24]>ClCCl>[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24].[NH2:7][C@@H:8]([CH2:9][C:10]1[CH:11]=[C:12]([F:17])[CH:13]=[C:14]([F:16])[CH:15]=1)[CH2:18][OH:19]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57881012(S)-2-Boc-amino-3-(3,5-difluorophenyl)propan-1-OL

Product 1

HCID 690152702-(S)-Amino-3-(3,5-difluorophenyl)-propan-1-ol trifluoroacetate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Dissolve [2-(3,5-difluorophenyl)-1-(S)-hydroxymethyl-ethyl]-carbamic acid tert-butyl ester (4.57 g, 15.9 mmol) in dichloromethane (20 mL). Add trifluoroacetic acid (20 mL) and stir 45 min and concentrate to give the title compound as a thick residue.

Workup

  1. concentrationconcentrate

Sources & evidence

ORD record
ord-9085fae18ef84c4bac9be173f4e75943
Source dataset
uspto-grants-2009_11
Patent number
US07618978B2

Reaction notes

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