反应详情

Add 1 N lithium hydroxide (19.5 mL, 19.5 mmol) to a solution of (S)-2-sec-butylamino-6-(methanesulfonyl-methylamino)-isonicotinic acid methyl ester (2.45 g, 7.77 mmol) in THF (10 mL) at 0° C. After 2 h at room temperature, acidify the mixture to about pH =2 and concentrate. Extract the residue with ethyl acetate (3×40 mL), wash the combined extracts with saturated aqueous sodium chloride, dry (magnesium sulfate) and concentrate to give the title compound as a yellow solid (2.23 g, 95%).

1. concentrationconcentrate
2. extractionExtract the residue with ethyl acetate (3×40 mL)
3. washwash the combined extracts with saturated aqueous sodium chloride
4. dry with materialdry (magnesium sulfate)
5. concentrationconcentrate