反应详情

Dissolve 5-benzoyl-N-methyl-N-propyl-isophthalamic acid methyl ester (60 mg, 0.17 mmol) in methanol (4 mL). Add dropwise 1 N lithium hydroxide (0.23 mL) and stir overnight at room temperature. Acidify the mixture to about pH=6 by 5 N HCl and concentrate to near dryness. Dilute the residue with ethyl acetate and wash with saturated aqueous sodium chloride solution, dry (magnesium sulfate) and concentrate to give the title compound (83%).

1. concentrationconcentrate to near dryness
2. additionDilute the residue with ethyl acetate
3. washwash with saturated aqueous sodium chloride solution
4. dry with materialdry (magnesium sulfate)
5. concentrationconcentrate