Hydrochloric Acid → HCID 69017376, compound

HRID 1436744Notes

Reaction equation

HRID 1436744 reaction equation
[ClH:1].O1CCOCC1.C(OC([N:15]1[CH2:20][C@H:19]([O:21][CH2:22][CH2:23][CH:24]([CH3:26])[CH3:25])[CH2:18][CH2:17][C@@H:16]1[C@H:27]1[O:31]C(C)(C)[N:29]([C:34](=[O:36])[CH3:35])[C@H:28]1[CH2:37][C:38]1[CH:43]=[C:42]([F:44])[CH:41]=[C:40]([F:45])[CH:39]=1)=O)(C)(C)C>>[ClH:1].[F:44][C:42]1[CH:43]=[C:38]([CH:39]=[C:40]([F:45])[CH:41]=1)[CH2:37][C@H:28]([NH:29][C:34](=[O:36])[CH3:35])[C@H:27]([OH:31])[C@H:16]1[CH2:17][CH2:18][C@@H:19]([O:21][CH2:22][CH2:23][CH:24]([CH3:26])[CH3:25])[CH2:20][NH:15]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 86615388HCID 86615388, compound

Product 1

HCID 69017376HCID 69017376, compoundYield 92%

Procedure

Add 4.0 M hydrogen chloride in dioxane (0.46 mL, 1.86 mmoles) to (2R, 5R)-2-{(4S, 5S)-3-Acetyl-4-[3,5-difluoro-benzyl]-2,2-dimethyl-oxazolidin-5-yl}-5-(3-methyl-butoxy)-piperidine-1-carboxylic acid tert-butyl ester (0.05 g, 0.09 mmol) and stir until all starting material is consumed. Concentrate to afford the title product as a white solid (0.04 g, 92%).

Workup

  1. customis consumed
  2. concentrationConcentrate

Sources & evidence

ORD record
ord-8fcbeba2d484403ba427f0fe3ddbdbbe
Source dataset
uspto-grants-2009_11
Patent number
US07618978B2

Reaction notes

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