Trifluoroacetic acid → HCID 86602768, compound

HRID 1436754Notes

Reaction equation

HRID 1436754 reaction equation
[F:1][C:2]([F:31])([F:30])[C:3]1[CH:4]=[C:5]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C@H:17]3[CH2:21][CH2:20][C@@H:19]([NH:22]C(=O)OC(C)(C)C)[CH2:18]3)=[O:16])[CH2:11][CH2:10]2)[CH:6]=[CH:7][CH:8]=1.[F:32][C:33]([F:38])([F:37])[C:34]([OH:36])=[O:35]>C(Cl)Cl>[F:32][C:33]([F:38])([F:37])[C:34]([OH:36])=[O:35].[F:32][C:33]([F:38])([F:37])[C:34]([OH:36])=[O:35].[F:31][C:2]([F:1])([F:30])[C:3]1[CH:4]=[C:5]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C@H:17]3[CH2:21][CH2:20][C@@H:19]([NH2:22])[CH2:18]3)=[O:16])[CH2:11][CH2:10]2)[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86602770HCID 86602770, compound

Product 1

HCID 86602768HCID 86602768, compoundYield 95.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-Butyl [(1R,3S)-3-(4-[3-(trifluoromethyl)phenyl]-piperazin-1-ylcarbonyl)-cyclopentyl]-carbamate (82 mg, 0.18 mmol) was treated with trifluoroacetic Acid (3 mL, 0.04 mol) in methylene chloride (3 mL) at room temperature for 1 h. The mixture was concentrated to provide the desired product (98 mg, 93%). MS calculated for C20H28F3N3O: (M+H) 384.3; found 384.2.

Workup

  1. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-69b996f11f854c33a50c219b226945da
Source dataset
uspto-grants-2009_11
Patent number
US07618970B2

Reaction notes

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