Acetone → HCID 178443389, compound

HRID 1437049Notes

Reaction equation

HRID 1437049 reaction equation
CO.[ClH:3].Cl.Cl.[OH:6][C:7]1[CH:30]=[CH:29][C:10]([CH2:11][NH:12][C:13]([NH:15][C:16]([NH:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])=[NH:17])=[NH:14])=[CH:9][CH:8]=1.[CH3:31][C:32]([CH3:34])=O>>[ClH:3].[CH3:31][C:32]1([CH3:34])[N:14]=[C:13]([NH:12][CH2:11][C:10]2[CH:9]=[CH:8][C:7]([OH:6])=[CH:30][CH:29]=2)[NH:15][C:16]([NH:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])=[N:17]1

Participants

5

Reactant 4

HCID 180AcetoneHCID 313Hydrochloric AcidHCID 887MethanolHCID 178443405HCID 178443405, compound

Product 1

HCID 178443389HCID 178443389, compound

Procedure

25 ml of methanol, 40 ml of acetone and 0.1 ml of concentrated hydrochloric acid were added to 1.9 g (4.5 mmol) of N1-(4-hydroxybenzyl)-N5-decyl-biguanide dihydrochloride, and the mixture was refluxed for 30 hours. The solvent was distilled off under reduced pressure, and the residue was recrystallized with 80% aqueous acetonitrile to obtain 0.4 g of colorless crystals having a melting point of 109 to 111° C.

Workup

  1. temperaturethe mixture was refluxed for 30 hours
  2. distillationThe solvent was distilled off under reduced pressure
  3. customthe residue was recrystallized with 80% aqueous acetonitrile

Sources & evidence

ORD record
ord-31057026bd1c4de0813ce87a3e6ae2d6
Source dataset
uspto-grants-2009_11
Patent number
US07622469B2

Reaction notes

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