Hydrochloric Acid → HCID 69061731, compound

HRID 1437065Notes

Reaction equation

HRID 1437065 reaction equation
[CH:1](=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].[ClH:11].Cl.[F:13][C:14]([F:30])([F:29])[O:15][C:16]1[CH:21]=[CH:20][C:19]([NH:22][C:23]([NH:25][C:26]([NH2:28])=[NH:27])=[NH:24])=[CH:18][CH:17]=1>C(O)C>[ClH:11].[CH2:2]([CH:1]1[N:22]([C:19]2[CH:20]=[CH:21][C:16]([O:15][C:14]([F:13])([F:29])[F:30])=[CH:17][CH:18]=2)[C:23]([NH2:24])=[N:25][C:26]([NH2:28])=[N:27]1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 31289NonanalHCID 178479483HCID 178479483, compound

Product 1

HCID 69061731HCID 69061731, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

100 ml of ethanol, 4.4 ml (25.6 mmol) of 1-nonanal, and 0.7 ml of concentrated hydrochloric acid were added to 5.0 g (16.8 mmol) of N1-(4-trifluoromethoxyphenyl)-biguanide hydrochloride, and the mixture was refluxed for 9 hours. The solvent was distilled off under reduced pressure, and the residue was recrystallized from hydrous ethanol to obtain 0.7 g of colorless crystals having a melting point of 216 to 220° C.

Workup

  1. temperaturethe mixture was refluxed for 9 hours
  2. distillationThe solvent was distilled off under reduced pressure
  3. customthe residue was recrystallized from hydrous ethanol

Sources & evidence

ORD record
ord-2fab78caa1b84b96b5a0ef6b69cae03a
Source dataset
uspto-grants-2009_11
Patent number
US07622469B2

Reaction notes

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