Acetone → HCID 178443483, compound

HRID 1437090Notes

Reaction equation

HRID 1437090 reaction equation
CO.[ClH:3].Cl.Cl.[C:6]1([NH:12][C:13]([NH:15][C:16]([NH:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])=[NH:17])=[NH:14])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[CH3:28][C:29]([CH3:31])=O>>[ClH:3].[NH2:14][C:13]1[N:12]([C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:29]([CH3:31])([CH3:28])[N:17]=[C:16]([NH:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[N:15]=1

Participants

5

Reactant 4

HCID 180AcetoneHCID 313Hydrochloric AcidHCID 887MethanolHCID 178443502HCID 178443502, compound

Product 1

HCID 178443483HCID 178443483, compound

Procedure

100 ml of methanol, 80 ml of acetone and 0.6 ml of concentrated hydrochloric acid were added to 9.0 g (23.9 mmol) of N1-phenyl-N5-nonyl-biguanide dihydrochloride. The mixture was refluxed for 24 hours, and the solvent was distilled off under reduced pressure. The residue was recrystallized from methyl ethyl ketone to obtain 3.8 g of colorless crystals having a melting of 134 to 137° C.

Workup

  1. temperatureThe mixture was refluxed for 24 hours
  2. distillationthe solvent was distilled off under reduced pressure
  3. customThe residue was recrystallized from methyl ethyl ketone

Sources & evidence

ORD record
ord-1488afd05ee54bcf999a3a53f292a9ab
Source dataset
uspto-grants-2009_11
Patent number
US07622469B2

Reaction notes

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