2-Bromoethyl ethyl ether → HCID 68895392, compound

HRID 1437195Notes

Reaction equation

HRID 1437195 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][CH:9]([C:12]2[C:20]3[C:15](=[CH:16][N:17]=[CH:18][CH:19]=3)[NH:14][CH:13]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2].Br[CH2:22][CH2:23][O:24][CH2:25][CH3:26]>>[CH2:1]([O:3][C:4]([N:6]1[CH2:7][CH2:8][CH:9]([C:12]2[C:20]3[C:15](=[CH:16][N:17]=[CH:18][CH:19]=3)[N:14]([CH2:22][CH2:23][O:24][CH2:25][CH3:26])[CH:13]=2)[CH2:10][CH2:11]1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 611412-Bromoethyl ethyl etherHCID 68895624HCID 68895624, compound

Product 1

HCID 68895392HCID 68895392, compoundYield 63%

Procedure

This compound was prepared following the procedure described in example 24, part C, starting with 1.05 g (3.84 mmol) of 4-(1H-pyrrolo[2,3-c]pyridin-3-yl)-piperidine-1-carboxylic acid ethyl ester and 0.52 ml (4.61 mmol) of 2-bromoethylethyl ether. After standard work-up and purification, 0.83 g (63% yield) 4-[1-(2-ethoxyethyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-piperidine-1-carboxylic acid ethyl ester were obtained.

Workup

  1. customThis compound was prepared
  2. customAfter standard work-up and purification

Sources & evidence

ORD record
ord-7cda3d56aef54757a08fd83dd7fc5e73
Source dataset
uspto-grants-2009_11
Patent number
US07622480B2

Reaction notes

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