反应详情

温度

165 °C

Copper(I) cyanide (2.68 g) was added to 2-bromo-6-methoxypyridine (5.62 g) in N,N-dimethylformamide (112 mL) at room temperature, followed by stirring at 165° C. for 15 hours. The resultant mixture was cooled in air. Water and ethyl acetate was added to the mixture. The insoluble matter that was formed in the mixture was filtered by Celite. The filtrate was partitioned between water and ethyl acetate. The organic layer was dried over sodium sulfate anhydrate, followed by filtration. The solvent was evaporated under reduced pressure. The residue was subjected to silica gel column chromatography (hexane-ethyl acetate), to thereby give the title compound as a solid substance (1.78 g, 44%).

1. customThe insoluble matter that was formed in the mixture
2. filtrationwas filtered by Celite
3. customThe filtrate was partitioned between water and ethyl acetate
4. dry with materialThe organic layer was dried over sodium sulfate anhydrate
5. filtrationfollowed by filtration
6. customThe solvent was evaporated under reduced pressure