Dimethylamine, hydrochloride → N,N-Dimethylpiperidine-2-carboxamide

HRID 1437252Notes

Reaction equation

C(O[N:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH:10]1[C:15]([OH:17])=O)C1C=CC=CC=1.Cl.[CH3:19][NH:20][CH3:21]>>[CH3:19][N:20]([CH3:21])[C:15]([CH:10]1[CH2:11][CH2:12][CH2:13][CH2:14][NH:9]1)=[O:17]

Participants

Reactant 2

HCID 10473Dimethylamine, hydrochloride

HCID 23090179N-benzyloxypiperidine-2-carboxylic acid

Product 1

HCID 14810940N,N-Dimethylpiperidine-2-carboxamide

Procedure

The general procedure of Referential Example 131 was repeated through use of N-benzyloxypiperidine-2-carboxylic acid (6.4 g) and dimethylamine hydrochloride (2 g), to thereby give the title compound as an oily product (3.8 g, quantitative amount).

Sources & evidence

ORD record: ord-53dcf794ab7046f6b03534758244f112
Source dataset: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07622471B2

Reaction notes

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