Methanol → HCID 91006379, compound

HRID 1437321Notes

Reaction equation

HRID 1437321 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][C:11]([C:15](=[O:27])[NH:16][C:17]2[CH:22]=[CH:21][N:20]=[C:19]3[O:23][CH2:24][CH2:25][O:26][C:18]=23)([OH:14])[CH2:10][CH2:9]1)(C)(C)C.CO>C(OCC)(=O)C>[O:26]1[C:18]2[C:19](=[N:20][CH:21]=[CH:22][C:17]=2[NH:16][C:15]([C:11]2([OH:14])[CH2:12][CH2:13][CH:8]([NH2:7])[CH2:9][CH2:10]2)=[O:27])[O:23][CH2:24][CH2:25]1

Participants

4

Reactant 2

HCID 887MethanolHCID 68704256HCID 68704256, compound

Product 1

HCID 91006379HCID 91006379, compoundYield 32%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

This was prepared from carbamate (b) (105 mg) by the procedure of Example (1m) with the exception that the crude material was subjected to chromatography on silica eluting with a 0-30% methanol in ethyl acetate gradient affording an oil (25 mg, 32%).

Sources & evidence

ORD record
ord-af30a5ca8de542aa9d1ed865185bcc89
Source dataset
uspto-grants-2009_11
Patent number
US07622481B2

Reaction notes

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