Sodium Hydroxide → 5-Methoxyquinolin-4-ol

HRID 1437361ノート

反応式

HRID 1437361 の反応式
Br[C:2]1[CH:3]=[CH:4][C:5]([O:13][CH3:14])=[C:6]2[C:11]=1[NH:10][CH:9]=[CH:8][C:7]2=[O:12].[OH-].[Na+]>O1C=COC=C1.[Pd]>[CH3:14][O:13][C:5]1[CH:4]=[CH:3][CH:2]=[C:11]2[C:6]=1[C:7](=[O:12])[CH:8]=[CH:9][NH:10]2

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 497579588-Bromo-5-methoxyquinolin-4-ol

生成物 1

HCID 235953245-Methoxyquinolin-4-ol収率 70%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 789681,4-Dioxin溶媒

実験手順

Quinolone (b) (5.4 g, 21 mmol) was dissolved in a mixture of dioxin (300 ml) and 2M aqueous sodium hydroxide solution (21 ml, 42 mmol) then hydrogenated over 10% palladium on charcoal (2.3 g) for 18 hours. The mixture was filtered, neutralised (5M hydrochloric acid) and concentrated when crystallisation commenced. Filtration, washing with water and drying in vacuo afforded a solid (2.5 g, 70%).

後処理

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated
  3. customwhen crystallisation
  4. filtrationFiltration
  5. washwashing with water
  6. customdrying in vacuo

出典と根拠

ORDレコード
ord-cd69544eef3c48f4a04550902c81f96d
出典データセット
uspto-grants-2009_11
特許番号
US07622481B2

反応ノート

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