4-Aminopyridine → HCID 59427333, compound

HRID 1437363Notes

Reaction equation

HRID 1437363 reaction equation
[CH3:1][C:2]1([CH3:10])[O:7][C:6](=[O:8])[CH2:5][C:4](=[O:9])[O:3]1.[NH2:11][C:12]1[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=1.[CH:18](OC)(OC)OC>>[CH3:1][C:2]1([CH3:10])[O:7][C:6](=[O:8])[C:5](=[CH:18][NH:11][C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)[C:4](=[O:9])[O:3]1

Participants

4

Reactant 3

HCID 17274-AminopyridineHCID 9005Trimethyl orthoformateHCID 162492,2-Dimethyl-1,3-dioxane-4,6-dione

Product 1

HCID 59427333HCID 59427333, compound

Procedure

A mixture of 2,2-dimethyl-[1,3]dioxane-4,6-dione (Meldrum's acid) (8.4 g, 59 mmol) and trimethyl orthoformate (50 mL) was heated to reflux for 2 hours. 4-Aminopyridine (5 g, 53 mmol) was added and the mixture heated for a further 0.25 hour. The resulting solid was washed with a small amount of cold ethanol and dried in vacuo (7.3 g, 55%).

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 2 hours
  3. temperaturethe mixture heated for a further 0.25 hour
  4. washThe resulting solid was washed with a small amount of cold ethanol
  5. customdried in vacuo (7.3 g, 55%)

Sources & evidence

ORD record
ord-a9b8084e632543679c1e4220eb7d6ea2
Source dataset
uspto-grants-2009_11
Patent number
US07622481B2

Reaction notes

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