Benzofuran-2-carboxylic acid → 2,3-Dihydro-1-benzofuran-2-carboxylic acid
Reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[C:10]([OH:12])=[O:11]>C(O)(=O)C.[OH-].[Pd+2].[OH-]>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH2:3][CH:2]1[C:10]([OH:12])=[O:11]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Conditions
- Temperature
- 60 °C
Procedure
A mixture of 1-benzofuran-2-carboxylic acid (40.0 g, 250.0 mmol) and palladium hydroxide (20 wt. % on carbon, 2.0 g) in acetic acid (400 ml) was heated at 60° C. under a hydrogen atmosphere (80 psi) for 2 h. The mixture was filtered to give a solution of the title compound (39.5 g) in acetic acid.
Workup
- filtrationThe mixture was filtered
Sources & evidence
- ORD record
- ord-99e45161e36b436d81e1c1c0182bb7d8
- Source dataset
- uspto-grants-2009_11
- Patent number
- US07622500B2
Reaction notes
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