Ethyl Acetate → HCID 24991587, compound

HRID 1437614Notes

Reaction equation

HRID 1437614 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([CH2:11][OH:12])[C:9]#[N:10].[C:13](OCC)(=[O:15])[CH3:14]>CCCCCC>[C:13]([O:12][CH2:11][CH:8]([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[Cl:1])[C:9]#[N:10])(=[O:15])[CH3:14]

Participants

4

Reactant 2

HCID 8857Ethyl AcetateHCID 66906071HCID 66906071, compound2×

Product 1

HCID 24991587HCID 24991587, compound

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

This ester was prepared using the procedure described in Example 5, except 2-(2-chlorophenyl)-3-hydroxypropanenitrile was used in place of 2-(2-chloro-5-(difluoromethoxy)phenyl)-3-hydroxypropanenitrile. The preparation of 2-(2-chlorophenyl)-3-hydroxypropanenitrile is described in Example 13. The recovered ester product was a colorless oil (70% yield), Rf 0.3 (silica gel, ethyl acetate:hexane=1:4).

Sources & evidence

ORD record
ord-362a429a95b04d0eba0fcf6307fe57b3
Source dataset
uspto-grants-2009_11
Patent number
US07622504B2

Reaction notes

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