反应详情

To a solution of the compound (0.15 g) obtained in Example 1 in THF (5.0 ml), Et3N (0.15 ml) was added, acetyl chloride (0.040 ml) was added at 0° C., and the reaction mixture was stirred at room temperature for 1 hour. The reaction mixture was poured into water, and then the product was extracted with ethyl acetate. The organic layer was washed with an aqueous 10% citric acid solution and saturated brine, dried, and then the solvent was evaporated under reduced pressure. The obtained residue was isolated and purified by silica gel column chromatography (ethyl acetate:hexane=1:1→1:0) to obtain the title compound as colorless oil (0.10 g, 66%).

1. extractionthe product was extracted with ethyl acetate
2. washThe organic layer was washed with an aqueous 10% citric acid solution and saturated brine
3. customdried
4. customthe solvent was evaporated under reduced pressure
5. customThe obtained residue was isolated
6. custompurified by silica gel column chromatography (ethyl acetate:hexane=1:1→1:0)