Pyrrolidine → Pyrrolidin-1-yl-[5-(3-pyrrolidin-1-yl-propoxy)-1H-pyrrolo[2,3-b]pyridin-2-yl]-methanone

HRID 1437695Notes

Reaction equation

HRID 1437695 reaction equation
[N:1]1([CH2:6][CH2:7][CH2:8][O:9][C:10]2[CH:11]=[C:12]3[CH:18]=[C:17]([C:19]([O-:21])=O)[NH:16][C:13]3=[N:14][CH:15]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[Li+].F[B-](F)(F)F.N1(OC(N(C)C)=[N+](C)C)C2C=[CH:34][CH:35]=[CH:36][C:31]=2[N:30]=N1.N1CCCC1.C(N(CC)C(C)C)(C)C>>[N:30]1([C:19]([C:17]2[NH:16][C:13]3=[N:14][CH:15]=[C:10]([O:9][CH2:8][CH2:7][CH2:6][N:1]4[CH2:2][CH2:3][CH2:4][CH2:5]4)[CH:11]=[C:12]3[CH:18]=2)=[O:21])[CH2:31][CH2:36][CH2:35][CH2:34]1

Participants

5

Reactant 4

HCID 31268PyrrolidineHCID 81531DiisopropylethylamineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 68423331lithium 5-(3-pyrrolidin-1-yl-propoxy)-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

Product 1

HCID 16727336Pyrrolidin-1-yl-[5-(3-pyrrolidin-1-yl-propoxy)-1H-pyrrolo[2,3-b]pyridin-2-yl]-methanoneYield 53%

Procedure

The title compound was synthesized in analogy to example 1 from lithium 5-(3-pyrrolidin-1-yl-propoxy)-1H-pyrrolo[2,3-b]pyridine-2-carboxylate, O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate, pyrrolidine and N,N-diisopropylethylamine to give the desired product as a light yellow solid (53%).

Sources & evidence

ORD record
ord-8ec911cefc594fc7b79c8bb333f1c916
Source dataset
uspto-grants-2009_11
Patent number
US07622466B2

Reaction notes

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